Otub1 noncanonical

Author: cmho

August undefined, 2024

WebSurprisingly, we found that OTUB1 suppresses RNF168-dependent poly-ubiquitination independently of its catalytic activity. OTUB1 does so by binding to and inhibiting UBC13 (also known as UBE2N), the cognate E2 enzyme for RNF168. This unusual mode of regulation is unlikely to be limited to UBC13 because analysis of OTUB1-associated … WebJun 22, 2024 · OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation Cell Death Dis. 2024 Jun 22;13 (6):560. …

Non-canonical inhibition of DNA damage-dependent …

WebJun 22, 2024 · OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation Cell Death Dis. 2024 Jun 22;13 (6):560. doi: 10.1038/s41419-022-05008-z. Authors WebNM1 Ø45 AC Manual Override Wired Tubular Motor, TUBE brand is owned and developed by Zhejiang LianDa Science & Technology Co.,Ldt., wholly owned company by the … olive garden italian restaurant hayward

OTUB1 stabilizes mismatch repair protein MSH2 by …

WebMay 13, 2024 · The processing of p100 is a central step in noncanonical NF-κB activation, which is stimulated by ligands of specific TNFR superfamily members, such as BAFF in … WebAug 4, 2024 · Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield Authors: Wang Shuansuo Chinese Academy... WebMar 18, 2024 · Otub1, an OTU family deubiquitinase, was found to interact with c-Maf by mass spectrometry. Otub1 abrogates c-Maf K48-linked polyubiquitination, thus … is a lender a s seleer in real estate

Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1

【标题速读】【Ncomm】【biological-sciences】【2024年】【8 …

WebAug 19, 2010 · OTUB1 inhibits K48-linked ubiquitination of HIF-1α via its non-canonical inhibition of ubiquitination activity OTUB1 was previously identified as a member of the ovarian tumor domain containing... WebJan 27, 2015 · OTUB1 mediates prostate cancer cell invasion through RhoA activation and promotes tumorigenesis in vivo. Our results suggest that drugs targeting the catalytic activity of OTUB1 could potentially be used as therapeutics for … is a lemon buy back a branded titleWebJan 1, 2024 · Otubain-1 (OTUB1) protease is identified as a novel amplifier of the proto-oncogene c-MYC, a critical cancer driver that correlates with inferior clinical outcomes in the c- MYC-dependent cancer multiple myeloma, and overexpression of OTUB1 accelerates the growth of myel cancer cells. 3 PDF is a lendistry grant taxable

"WebMay 5, 2015 · Notably, one of the OTU family members, OTUB1, modulates the response to DNA breaks by countering ubiquitination in a noncanonical fashion (Nakada et al, 2010 ). Instead of utilizing its own DUB activity, OTUB1 binds to and inhibits specific E2 ligases involved in the DNA damage response (Nakada et al, 2010 ). " - Otub1 noncanonical

Otub1 noncanonical

Depletion of OTUB1 represses TGFβ-induced …

WebAug 1, 2010 · OTUB1 does so by binding to and inhibiting UBC13 (also known as UBE2N), the cognate E2 enzyme for RNF168. This unusual mode of regulation is unlikely to be limited to UBC13 because analysis of OTUB1-associated proteins revealed that OTUB1 binds to E2s of the UBE2D and UBE2E subfamilies. WebMar 12, 2024 · Mechanistically, OTUB1 prevented necroptosis by reducing K48-dependent proteasomal degradation of c-IAP1, thereby, enabling c-IAP1-mediated K63-linked polyubiquitination of RIPK1. Thus, OTUB1...

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WebMay 13, 2024 · Thus, the hyper-production of IL-6 in Otub1-BKO mice was in line with the aberrant activation of canonical and noncanonical NF-κB in Otub1-deficient B cells. …

WebJan 1, 2024 · Otubain-1 (OTUB1) protease is identified as a novel amplifier of the proto-oncogene c-MYC, a critical cancer driver that correlates with inferior clinical outcomes in … WebApr 14, 2024 · 56.Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform. ... 257.Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to …

WebJun 22, 2024 · In addition, OTUB1 inhibits K48-linked polyubiquitination of HIF-1α via its non-canonical inhibition of ubiquitination activity. Furthermore, OTUB1 promotes hypoxia … WebMar 21, 2024 · OTUB1 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1) is a Protein Coding gene. Diseases associated with OTUB1 include Machado-Joseph Disease and Autosomal Dominant Cerebellar Ataxia.Among its related pathways are Deubiquitination and Metabolism of proteins.Gene Ontology (GO) annotations related to this gene include …

WebJan 1, 2024 · A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer-associated signaling pathways including MAPK, ERa, epithelial …

WebMar 3, 2012 · OTUB1 N-terminal arm and the mechanism of E2 inhibition. ... Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell. 1999; 96:645–653. [Google Scholar] 11. Yin L, Krantz B, Russell NS, Deshpande S, Wilkinson KD. Nonhydrolyzable diubiquitin analogues are inhibitors of ... olive garden italian restaurant hickoryWebMar 1, 2024 · After extensive characterizations, we have identified a TRAF3-binding protein, TFG, and a p100-binding protein, Otub1, which are critically involved in noncanonical … olive garden italian restaurant hickory ncWebMar 1, 2024 · After extensive characterizations, we have identified a TRAF3-binding protein, TFG, and a p100-binding protein, Otub1, which are critically involved in noncanonical NF-?B regulation. TFG is crucial for preventing abnormal NIK accumulation, whereas Otub1 is a deubiquitinase (DUB) that inhibits p100 ubiquitination and processing. olive garden italian restaurant heath ohWebApr 1, 2024 · It is well-defined that OTUB1 also possesses a noncanonical function independently of its deubiquitinase activity, which inhibits the ubiquitination of target … olive garden italian restaurant hialeah flWebOTUB1 possesses a non-canonical, catalytic-independent activity where it inhibits the transfer of ubiquitin onto protein substrates by binding to the ubiquitin-charged E2. This review will describe the canonical and non-canonical activities of OTUB1, summarize OTUB1’s regulation of cancer-associated pathways and discuss OTUB1’s potential olive garden italian restaurant high pointWebnonical way, OTUB1 acts as a cysteine protease to directly deubiquitinate its substrates (22). OTUB1 also works in a noncanonical way by interacting with E2 enzymes to inhibit the ubiquitin transfer to substrates that are involved in diverse * For correspondence: Zhijie Chang, [email protected]; Guo-Min biological pathways (24, 25). olive garden italian restaurant hayward caWebMar 18, 2024 · Otub1 functions as a canonical deubiquitinase by cleaving conjugated Ub chains18 or acts in a noncanonical manner by binding to certain E2 enzymes to prevent Ub chain transfer.19 To find which mechanism is important for Otub1 in c-Maf ubiquitination, we mutated K71, D88, and C91, which are critical for its protease activity, and deleted the N ... olive garden italian restaurant horseheads