Summing up the noise in gene networks

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Web1 Apr 2008 · Several lines of evidence (9–13, 17) point to slow transitions between active and inactive promoter states as an important source of noise in gene expression, which is responsible for generating heterogeneity in the response … Web29 Jan 2004 · Abstract. Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects all life processes and has recently been measured using green fluorescent protein (GFP).

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WebSearch. Quicklinks. Suggestion for acquisition; classic Library Catalogue (OPAC) Common Union Catalogue (GVK) Web26 May 2012 · Paulsson J (2004) Summing up the noise in gene networks. Nature 427: 415–418. Article Google Scholar Paulsson J (2005) Models of stochastic gene expression. Phys Life Rev 2: 157–175. Article Google Scholar Peccoud J, Ycart B (1995) Markovian modelling of gene-product synthesis. tribute\u0027s 7j

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Web23 Nov 2008 · Paulsson, J. Summing up the noise in gene networks. Nature 427, 415–418 (2004). Article CAS Google Scholar ... Web3 Jul 2001 · Transient noise for a single gene. The protein half-life is fixed at 1 h, b = 20, and kR = 0.01 s −1. Exact analytic results are plotted for an mRNA half-life of 120, 24, and 0 s, corresponding to η = 1/30, 1/150, and 0, respectively. δ … WebThe two-reporter experimental setup designed for decomposition of observed noise into extrinsic and intrinsic components has been used successfully to study noise contributed by global effects and gene-specific effects, as well as pathway-specific effects (4, 6, 18). tribute\u0027s jo

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Noise-Limited Frequency Signal Transmission in Gene Circuits

Web1 Jan 2004 · Summing up the noise in gene networks. Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such `noise' affects all life processes and has recently been measured using green fluorescent protein (GFP). Web1 Dec 2007 · Increasing decay rate constants can speed up enzymatic kinetics and increase noise frequencies in simple gene circuits ... Summing up the noise in gene networks. ... Intrinsic noise in gene regulatory networks. Proc. Natl. Acad. Sci. USA, 98 … tribute\u0027s 0jWeb1 Jan 2004 · Abstract. Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects all life processes and has recently been measured using green fluorescent protein (GFP). tribute\u0027s kw

"WebPaulsson, J. (2004). Summing up the noise in gene networks. Nature, 427(6973), 415–418. doi:10.1038/nature02257 " - Summing up the noise in gene networks

Summing up the noise in gene networks

Noise Propagation and Signaling Sensitivity in Biological Networks: A R…

Web3 Jul 2001 · We find for a single gene that noise is essentially determined at the translational level, and that the mean and variance of protein concentration can be independently controlled. The noise strength immediately following single gene induction is almost twice the final steady-state value. WebRandom fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects all life processes and has recently …

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Web19 Jan 2024 · However, how living systems deal with noise while performing desirable biological functions remains a major mystery. Regulatory network congurations, such as their topology and timescale, are shown to be critical in attenuating noise, and noise is also found to facilitate cell fate decision. WebSumming up the noise in gene networks Published in: Nature, January 2004 DOI: 10.1038/nature02257: Pubmed ID: 14749823. Authors: Johan Paulsson Abstract: Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects …

Web1 Feb 2004 · Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects all... WebSumming up the noise Johan Paulsson Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544-1014 Random fluctuations in genetic networks are inevitable since chemical reactions are probabilistic and many genes, mRNAs and proteins are present in low numbers per cell. Such ‘noise’ affects

WebPaulsson, J. (2004) Summing up the noise in gene net works. Nature, 427, 415-418. doi10.1038/nature02257 ... Filtering noises in gene networks using biological techniques accompanied with a systematic strategy is thus an attractive topic. However, most states of biological systems are not directly accessible. In practice, these immeasurable ... Web29 Jan 2004 · Physics Nature Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such ‘noise’ affects all life processes and has recently been measured using green fluorescent protein (GFP).

Web14 Jan 2008 · Summing Up the Noise in Gene Networks. Article. Feb 2004; NATURE; Johan Paulsson; Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes ...

Web4 Jan 2008 · We explore for gene circuits that can buffer propagated noise while maintaining signaling sensitivity. We consider a large set of networks that are differentially designed but are equally sensitive to long-term changes in the input, and compare their ability to buffer propagated noise. tribute\u0027s rzWeb29 Jan 2004 · Noise in genetic and metabolic networks can be detrimental to fitness—randomizing developmental pathways, disrupting cell cycle control or forcing metabolites away from their optimal levels. It ... tribute\u0027s j6Web1 Jun 2000 · A ball (representing the level of gene expression) rolling in a salad bowl (representing the gene network) will ultimately come to rest at the bottom of the bowl. Shaking the bowl (the... tribute\u0027s kiWeb1 Aug 2009 · In this paper, we investigate the problem how to establish the robust stability of uncertain gene networks with time-varying delays and noise. Specifically, we consider uncertain gene networks where the regulation occurs at the mRNAs level, and we obtain a sufficient condition for robust stability by Lyapunov method and inequality technique. tribute\u0027s sjWebLocal adaptation and plasticity of growth play important roles in the adaptability of trees to changing conditions. Under accelerating climatic changes, the adaptive capacity of metapopulations can be exceeded, implying a necessity for assisted gene flow to sustain the productivity of forests. Such management is knowledge intensive, and information on … tribute\u0027s jlWeb25 Mar 2005 · The second noise component, the transmitted intrinsic noise (Fig. 3A, blue arrows), includes the transmitted fluctuations of each of the upstream genes in the network and depends on three factors: the intrinsic noise for that upstream gene; the effect of temporal averaging (6, 16), which depends on the lifetimes of the proteins; and the … tribute\u0027s vlWeb29 Jan 2004 · Random fluctuations in genetic networks are inevitable as chemical reactions are probabilistic and many genes, RNAs and proteins are present in low numbers per cell. Such 'noise' affects all life processes and has recently been measured using green fluorescent protein (GFP). Two studies show that negative feedback suppresses noise, … tribute\u0027s k4